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- Title
Daily Step Count and All-Cause Mortality: A Dose–Response Meta-analysis of Prospective Cohort Studies.
- Authors
Jayedi, Ahmad; Gohari, Ali; Shab-Bidar, Sakineh
- Abstract
Background: Uncertainty remains about the optimum step count per day for health promotion. Objective: We aimed to investigate the association between step count per day and all-cause mortality risk. Methods: PubMed, Scopus, and ISI Web of Science were searched to January 2021 to find prospective cohort studies of the association between device-based step count per day and all-cause mortality risk in the general population. Two reviewers extracted data in duplicate and rated the certainty of evidence using the GRADE approach. Study-specific hazard ratios (HRs) were pooled using a random-effects model. Results: Seven prospective cohort studies with 175,370 person-years and 2310 cases of all-cause mortality were included. The HR for each 1000 steps per day was 0.88 (95% CI 0.83–0.93; I2 = 79%, n = 7) in the overall analysis, 0.87 (95% CI 0.78–0.97; I2 = 59%, n = 3) in adults older than 70 years, and 0.92 (95% CI 0.89–0.95; I2 = 37%, n = 2) in studies controlled for step intensity. Dose–response meta-analysis indicated a strong inverse association, wherein the risk decreased linearly from 2700 to17,000 steps per day. The HR for 10,000 steps per day was 0.44 (95% CI 0.31–0.63). The certainty of evidence was rated strong due to upgrades for large effect size and dose–response gradient. Conclusions: Even a modest increase in steps per day may be associated with a lower risk of death. These results can be used to develop simple, efficient and easy-to-understand public health messages.
- Subjects
CAUSES of death; ONLINE information services; META-analysis; GAIT in humans; SYSTEMATIC reviews; UNCERTAINTY; PHYSICAL activity; DESCRIPTIVE statistics; MEDLINE
- Publication
Sports Medicine, 2022, Vol 52, Issue 1, p89
- ISSN
0112-1642
- Publication type
Article
- DOI
10.1007/s40279-021-01536-4