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- Title
Associations between migraine and dyslipidaemia in the E3N cohort study.
- Authors
MacDonald, C. J.; Madika, A. L.; Menegaux, F.; Boutron-Ruault, M. C.
- Abstract
Background: Previous case-control and cross-sectional studies have suggested that migraine is associated with an increased likelihood of dyslipidaemia, but it is uncertain if these associations are driven by lifestyle factors such as weight and exercise. This study aimed to explore cross-sectional associations between migraine and dyslipidaemia, whilst controlling for multiple potential confounders, including BMI and physical activity. Methods: We included 71,582 women from the E3N study, who had provided information on migraine and dyslipidaemia in questionnaires. Dyslipidaemia and migraine were based on self-reports. Logistic regression models were used to assess the association between migraine and prevalent dyslipidaemia, controlling for potential confounders including BMI. As a sensitivity analysis, only dyslipidaemia cases with reimbursement for lipid-lowering medications were considered valid. Results: Women were at a mean age of 70.9 years at inclusion. Dyslipidaemia was reported by 32,271 women and were reimbursed for lipid-lowering medications in 71.1% (n = 22,919) of cases. History of migraine was reported by 19,589 women. In unadjusted models, ever history of all migraine was not associated with the odds of dyslipidaemia (OR migraine = 1.01 [0.98: 1.05], p = 0.41), but this association was positive after adjusting for potential confounding factors such as age, BMI, and physical activity (OR migraine = 1.04 [1.01: 1.08], p = 0.02) and was consistent when considering only treated dyslipidaemia (OR migraine = 1.04 [1.00: 1.08], p = 0.03). Conclusions: Migraine was associated with an increase in likelihood of dyslipidaemia, regardless of BMI and physical activity. Key messages: Migraine is a disease with high prevalence in women. History of migraine is associated with an increased risk of dyslipidaemia.
- Subjects
MIGRAINE; CONFERENCES &; conventions; HYPERLIPIDEMIA; PHYSICAL activity; BODY mass index
- Publication
European Journal of Public Health, 2021, Vol 31, piii424
- ISSN
1101-1262
- Publication type
Article