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- Title
Understanding respiratory microbiome–immune system interactions in health and disease.
- Authors
Di Simone, Sara K.; Rudloff, Ina; Nold-Petry, Claudia A.; Forster, Samuel C.; Nold, Marcel F.
- Abstract
Interactions between the developing microbiome and maturing immune system in early life are critical for establishment of a homeostasis beneficial to both host and commensals. The lung harbors a diverse community of microbes associated with health and local or systemic disease. We discuss how early life colonization and community changes correlate with immune development and health and disease throughout infancy, childhood, and adult life. We highlight key advances in microbiology, immunology, and computational biology that allow investigation of the functional relevance of interactions between the respiratory microbiome and host immune system, which may unlock the potential for microbiome-based therapeutics.
- Subjects
RESPIRATORY organs; COMPUTATIONAL biology; COMMENSALISM; IMMUNE system; COMMUNITIES; MICROBIOLOGY; CHILDHOOD obesity
- Publication
Science Translational Medicine, 2023, Vol 15, Issue 678, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.abq5126