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- Title
SYNTHESIS, CHARACTERIZATION, ANTI-MICROBIAL AND CYTOTOXIC APPLICATIONS OF ZINC(II) COMPLEXES.
- Authors
Tariq, Muhammad; Batool, Atia; Abbas, Naseem; Hussain, Ajaz; Qureshi, Ahmad Kaleem; Shirazi, Jafir Hussain
- Abstract
In the present research, three zinc(II) complexes were synthesized using 3-(3-fluorophenyl)-2- methylacrylic acid (HL), 1,10-phenanthroline and 2,2'-pyridine as ligands. The composition, structural confirmation, coordination way of ligand and assignment of geometry to the complexes were made by different analytical tools like elemental analysis, FTIR and 1H-NMR. The ligand 3-(3-fluorophenyl)-2-methylacrylate appeared to coordinate the metal (Zn) atom via COO- moiety in all of the complexes (1-3) while 1,10- phenanthroline and 2,2'-pyridine co-ordinated to Zn(II) atom through N-donor sites in complexes 2 and 3, respectively. The complex 1 showed four while 2 and 3 showed six co-ordinated geometry. The synthesized complexes were evaluated for antimicrobial and cytotoxic activities. The obtained results showed that complexes are active against microbial agents and exhibited significant cytotoxicity.
- Subjects
METHACRYLIC acid; ZINC; ELEMENTAL analysis; PHENANTHROLINE; ZINC compounds synthesis
- Publication
Bulletin of the Chemical Society of Ethiopia, 2021, Vol 35, Issue 2, p287
- ISSN
1011-3924
- Publication type
Article
- DOI
10.4314/bcse.v35i2.6