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- Title
COVID-19 prognosis: what we know of the significance and prognostic value of liver-related laboratory parameters in SARS-CoV-2 infection.
- Authors
Bashash, Davood; Olfatifar, Meysam; Hadaegh, Farzad; Aghdaei, Hamid Asadzadeh; Zali, Mohammad Reza
- Abstract
Aim: The present study aims to evaluate the prognostic value of liver-related laboratory parameters in COVID-19. Background: This is not the first nor will it be the last time that a member of the β-coronaviruses wages a full-scale war against human health. Notwithstanding atypical pneumonia being the primary symptom, the emergence of severe disease mainly resulting from the injury of non-pulmonary organs leaves no alternative, in some cases, other than a dreadful death. Methods: To provide a well-conceptualized viewpoint representing the prognostic values of liver-related laboratory parameters in COVID-19, a meta-analysis was performed with the calculation of mean difference and 95% confidence intervals of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Bili), and albumin (Alb) in severe and non-severe COVID- 19 patients. Results: While severe COVID-19 cases displayed higher values of ALT, AST, and Bili compared to non-severe patients (mean differences of 7.48, 12.07, and 3.07, respectively), the value of Alb was significantly lower in severe cases (mean differences of - 6.15). There was also a correlation between alterations in all of the parameters; however, only correlations between ALT and Bili (R=0.98, p=0.0031), and Bili and Alb (R=-1, p=0.0012) were significant. Conclusion: Abnormal values of liver-related examinations outwardly contribute to reflect the progression of the disease toward an unfavorable outcome. Therefore, careful scrutiny of these parameters will provide clinicians with invaluable information regarding SARS-CoV-2 infection, at least in terms of liver injury.
- Subjects
ASPARTATE aminotransferase; BILIRUBIN; CONFIDENCE intervals; CLINICAL pathology; MEDLINE; META-analysis; ONLINE information services; SERUM albumin; ALANINE aminotransferase; COVID-19
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2020, Vol 13, Issue 4, p313
- ISSN
2008-2258
- Publication type
Article