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- Title
Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma.
- Authors
Shadifar, Mohammad; Ataee, Ramin; Ataie, Amin; Heydari Gorgi, Ali Morad; Nasrabadi, Nafiseh Nasri; Nouri, Somayyeh
- Abstract
Gastric adenocarcinoma is one of the most common malignancies worldwide. Many ethological causes have been introduced among which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with different digestive diseases, such as gastritis, peptic ulcer, and mucosa-associated lymphoid tissue lymphoma. Recently, scientists have been described some molecular aspects that show the role of some apoptotic genes and proteins; for example: P53, Bcl2, C-Myc and Rb-suppressor systems in the H. pylori pathogenesis. Also the relationship between nitric oxide (NOSi genotype) with H. pylori infection has been shown. The aim of this mini-review is to explain better these genetically aspects of H.pylori pathogenesis.
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2015, Vol 8, pS15
- ISSN
2008-2258
- Publication type
Article