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- Title
Introducing biomarker panel in esophageal, gastric, and colon cancers; a proteomic approach.
- Authors
Zamanian-Azodi, Mona; Rezaei-Tavirani, Mostafa; Hasanzadeh, Hadi; Rad, Sara Rahmati; Dalilan, Sona; Gilanchi, Samira; Manzour, Haleh
- Abstract
Cancer research is an attractive field in molecular biology and medicine. By applying large-scale tools such as advanced genomics and proteomics, cancer diagnosis and treatment have been improved greatly. Cancers of esophagus, gastric, and colon accounted for major health problem globally. Biomarker panel could bring out the accuracy for cancer evaluation tests as it can suggest a group of candidate molecules specified to particular malignancy in a way that distinguishing malignant tumors from benign, differentiating from other diseases, and identifying each stages with high specificity and sensitivity. In this review, a systematic search of unique protein markers reported by several proteomic literatures are classified in their specific cancer type group as novel panels for feasible accurate malignancy diagnosis and treatment. About thousands of introduced proteins were studied; however, a small number of them belonged to a specific kind of malignancy. In conclusion, despite the fact that combinatorial biomarkers appear to be hopeful, more evaluation of them is crucial to achieve the suitable biomarker panel for clinical application. This effort needs more investigations and researches for finding a specific and sensitive panel.
- Subjects
EPITHELIAL cell tumors; ADENOCARCINOMA; BIOMARKERS; CANCER patients; COLON tumors; GASTROENTEROLOGY; ESOPHAGEAL tumors; GASTROESOPHAGEAL reflux; MOLECULAR biology; SERIAL publications; OPERATIVE surgery; STOMACH tumors; TUMOR markers; PROTEOMICS; DIAGNOSIS; TUMOR risk factors
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2015, Vol 8, Issue 1, p6
- ISSN
2008-2258
- Publication type
Article