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- Title
Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection.
- Authors
Kanda, Tatsuo; Sasaki, Reina; Masuzaki, Ryota; Matsumoto, Naoki; Ogawa, Masahiro; Moriyama, Mitsuhiko
- Abstract
Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.
- Subjects
VIRAL hepatitis; VIRUS diseases; CELL culture; HEPATITIS A; DRUG target
- Publication
Viruses (1999-4915), 2020, Vol 12, Issue 5, p533
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v12050533