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- Title
The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.
- Authors
Pranata, Raymond; Supriyadi, Rudi; Huang, Ian; Permana, Hikmat; Lim, Michael Anthonius; Yonas, Emir; Soetedjo, Nanny Natalia M; Lukito, Antonia Anna
- Abstract
Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients. Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator. Results: Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], P =.03; I 2 = 51%, P =.01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], P =.009; I 2 = 14%, P =.32) and severe COVID-19 (RR 2.89 [0.98, 8.46], P =.05; I 2 = 57%, P =.04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], P <.001; I 2 = 87%, P <.001), including mortality (RR 26.02 [5.01, 135.13], P <.001; I 2 = 60%, P =.06), severe COVID-19 (RR 12.95 [1.93, 86.82], P =.008; I 2 = 81%, P <.001), intensive care (IC) (RR 14.22 [1.76, 114.62], P <.01; I 2 = 0%, P <.98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], P <.0005). Conclusion: CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.
- Subjects
CHRONIC kidney failure complications; CHRONIC kidney failure; INTENSIVE care units; KIDNEY diseases; META-analysis; ADULT respiratory distress syndrome; THERAPEUTICS; SYSTEMATIC reviews; MECHANICAL ventilators; TREATMENT effectiveness; SEVERITY of illness index; DESCRIPTIVE statistics; COVID-19; DISEASE risk factors; EVALUATION
- Publication
Clinical Medicine Insights: Circulatory, Respiratory & Pulmonary Medicine, 2020, p1
- ISSN
1179-5484
- Publication type
Article
- DOI
10.1177/1179548420959165