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- Title
Milk Fermented by Lactobacillus paracasei NCC 2461 (ST11) Modulates the Immune Response and Microbiota to Exert its Protective Effects Against Salmonella typhimurium Infection in Mice.
- Authors
Acurcio, Leonardo Borges; Wuyts, Sander; de Cicco Sandes, Sávio Henrique; Sant'anna, Felipe Machado; Pedroso, Silvia Helena Sousa Pietra; Bastos, Rafael Wesley; dos Reis, Diego Carlos; Vieira, Andréa Faria; Cassali, Geovanni Dantas; Lebeer, Sarah; de Souza, Marcelo Resende; Nicoli, Jacques Robert
- Abstract
Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probiotic effects of milk fermented by L. paracasei ST11 (administered through fermented milk) in a Salmonella typhimurium infection model in BALB/c mice. We observed in this murine model that the applied probiotic conferred protective effects against S. typhimurium infection, since its administration reduced mortality, weight loss, translocation to target organs (liver and spleen) and ileum injury. Moreover, a reduction in the mRNA expression of pro-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-17 in animals that received the probiotic before challenge was observed. Additionally, the ileum microbiota was better preserved in these animals. The present study highlights a multifactorial protective aspect of this commercial probiotic strain against a common gastrointestinal pathogen.
- Publication
Probiotics & Antimicrobial Proteins, 2020, Vol 12, Issue 4, p1398
- ISSN
1867-1306
- Publication type
Article
- DOI
10.1007/s12602-020-09634-x