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- Title
Erythrocyte Cation Content, Globin Chain Synthesis and Glucose Metabolism in Dysmyelopoietic Syndromes.
- Authors
Cetto, Gian Luigi; Vettore, Luciano; de Matteis, Maria Concetta; Piga, Andrea; Verona, Giuseppe
- Abstract
Red blood cells (RBC) from 13 patients suffering from dysmyelopoietic syndromes (DMPS) have been studied. About half of these subjects showed an abnormal Na+ and K+ leakage of their RBC, which were incubated at 37 °C for 24 h. The mean rate of the glycolytic pathway increased significantly and the glycolysis values correlated well with the Na+ gain. Moreover, 9 out of the 13 patients showed an abnormal biosynthetic ratio of haemoglobin chains in their reticulocytes. Since the multiple defects in DMPS erythrocytes do not seem clearly linked by cause-effect relationships, they probably derive from several cooperating factors in pathological erythroid precursors, leading to RBC membrane damage. Copyright © 1982 S. Karger AG, Basel
- Publication
Acta Haematologica, 1982, Vol 68, Issue 2, p124
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000206963