We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na<sup>+</sup>/K<sup>+</sup>-ATPase-Beclin-1 interaction.
- Authors
Banjac, Katarina; Obradovic, Milan; Zafirovic, Sonja; Isenovic, Esma R.
- Abstract
Introduction: Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods: Male Wistar rats were treated with IGF-1 (50 μg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α1 subunit of sodium/potassium-adenosine triphosphates (Na+/K+-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured. Results: The results indicate that IGF-1 decreased Beclin-1's association with Na+/K+-ATPase (p < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (p < 0.05), and decreased AMPK phosphorylation (p < 0.01) in rats' hearts. Conclusions: The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality.
- Subjects
PROTEIN kinases; FORKHEAD transcription factors; AMP-activated protein kinases; INSULIN receptors; LABORATORY rats
- Publication
Archives of Medical Science, 2024, Vol 20, Issue 3, p1011
- ISSN
1734-1922
- Publication type
Article
- DOI
10.5114/aoms/177618