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- Title
The Effects of N-Acetylcysteine and Deferoxamine on Plasma Cytokine and Oxidative Damage Parameters in Critically Ill Patients With Prolonged Hypotension: A Randomized Controlled Trial.
- Authors
Fraga, Cassiana Mazon; Tomasi, Cristiane Damiani; Biff, Daiane; Topanotti, Maria Fernanda Locks; Felisberto, Francine; Vuolo, Francieli; Petronilho, Fabricia; Dal-Pizzol, Felipe; Ritter, Cristiane
- Abstract
Reactive oxygen species and inflammation have been implicated in renal tubule cell injury. However, there is some controversy concerning whether antioxidants might attenuate oxidative damage and inflammation in humans after hypotension in the setting of critical illness. This study was a prospective, randomized, double-blinded, placebo-controlled study that included patients with hypotension. Patients were randomized to receive either N-acetylcysteine (NAC; 50 mg/kg by 4 hours followed by 100 mg/kg/d for 48 hours diluted in 5% glucose) and deferoxamine (DFX; at a single dose of 1000 mg diluted in 5% glucose) or placebo. The primary study outcome was the serum levels of markers of oxidative damage and inflammatory response. Secondary outcomes included the incidence of acute renal failure, serum creatinine at hospital discharge, intensive care unit length of stay, and length of hospital stay. Thirty patients were enrolled in the study. The use of NAC plus DFX decreased the oxidative damage parameters but not plasma interleukin-6 levels. In contrast, plasma nitrite levels increased 24 hours after NAC plus DFX administration. On analysis of secondary outcomes, it was observed that creatinine levels at hospital discharge were lower in patients receiving NAC plus DFX when compared with placebo. NAC plus DFX administration was able to decrease plasma markers of oxidative damage and creatinine levels at hospital discharge.
- Subjects
BRAZIL; PATIENTS; HYPOTENSION; ACUTE kidney failure; APACHE (Disease classification system); BIOMARKERS; CHI-squared test; CREATININE; CRITICALLY ill; CYTOKINES; DEFEROXAMINE; LENGTH of stay in hospitals; INTENSIVE care units; LONGITUDINAL method; RESEARCH funding; STATISTICAL sampling; SCALES (Weighing instruments); T-test (Statistics); U-statistics; RANDOMIZED controlled trials; BLIND experiment; SEVERITY of illness index; DATA analysis software; ACETYLCYSTEINE; DESCRIPTIVE statistics; DISEASE risk factors
- Publication
Journal of Clinical Pharmacology, 2012, Vol 52, Issue 9, p1365
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1177/0091270011418657