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- Title
Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol.
- Authors
Sierra Matiz, Oscar R.; Santilli, Juliana; Anai, Leticia A.; Da Silva, Maria C. L.; Sueiro, Felipe A.; Sequeira, Júlio L.; Magalhães, Larissa F.; Magalhães, Geórgia M.; Tinucci Costa, Mirela; Calazans, Sabryna G.
- Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cm2 were counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant (p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol.
- Subjects
DIFFUSE large B-cell lymphomas; LYMPHOMAS in dogs; PROTEIN expression; VETERINARY therapeutics; THERAPEUTICS
- Publication
Journal of Veterinary Diagnostic Investigation, 2018, Vol 30, Issue 2, p263
- ISSN
1040-6387
- Publication type
Article
- DOI
10.1177/1040638717743280