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- Title
Expression of glucose transporter-1 and insulin receptor α1 in osteoblast obtained from diabetic rats' mandibles.
- Authors
Wu Xuan; Liu Hongchen; Lingling, E.; Li Zhenchun
- Abstract
Objective To explore the expression of glucose transporter (GLUT)-1 and insulin receptor(IR) α1 in osteoblast obtained from diabetic rats' mandibles. Methods The expression of GLUT-1 and IR α1 of diabetic and control groups were measured by reverse transcription polymerase chain reaction, Western blot and immunohistochemistry stain. Results The mRNA expressions of GLUT-1 and IR α1 of diabetic group were significantly higher than control group (P<0.05). The protein expressions of GLUT-1 and IR α1 were similar to the mRNA expressions. Conclusion Osteoblasts obtained from diabetic rats' mandibles keep the adaptation changes to hyperglycemia and hypoinsulinemia, which may contribute to their dysfunction.
- Publication
West China Journal of Stomatology, 2011, Vol 29, Issue 4, p348
- ISSN
1000-1182
- Publication type
Article
- DOI
10.3969/j.issn.1000-1182.2011.04.003