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- Title
Serum Lipocalin 2 (Neutrophil Gelatinase-Associated Lipocalin) in Relation to Biomarkers of Inflammation and Cardiac Stretch During Activation of the Renin-Angiotensin-Aldosterone System in Human Immunodeficiency Virus.
- Authors
Bogorodskaya, Milana; Fitch, Kathleen V; Burdo, Tricia H; Maehler, Patrick; Easly, Rebecca M; Murray, Gillian R; Feldpausch, Meghan; Adler, Gail K; Grinspoon, Steven K; Srinivasa, Suman
- Abstract
<bold>Purpose: </bold>To evaluate the relationship of lipocalin 2 to inflammation and cardiac injury with increased aldosterone in human immunodeficiency virus (HIV).<bold>Methods: </bold>A standardized 6-day low-sodium diet was used to stimulate renin-angiotensin-aldosterone system (RAAS) activation, and serum lipocalin 2 and biomarkers of inflammation and cardiac stretch were assessed among persons with or without HIV.<bold>Results: </bold>Lipocalin 2 levels increased with RAAS activation compared with suppression in the HIV group (median level [interquartile range], 71.3 [59.2-99.7] vs 67.0 [51.8-86.3] ng/mL; P = .01). During RAAS activation, lipocalin 2 was related to biomarkers of inflammation (tumor necrosis factor α [P = .007]), monocyte/macrophage activation (soluble CD163 [P = .005] and chemokine [C-C motif] ligand 2 [P = .03]), and markers of cardiac stretch (brain natriuretic peptide [P < .001] and N-terminal fragment of the prohormone brain natriuretic peptide [P = .001]) in HIV.<bold>Conclusion: </bold>Lipocalin 2 may be important in modulating aldosterone-induced inflammation, monocyte activation, and cardiac stretch during RAAS activation in HIV.<bold>Clinical Trial Registration: </bold>NCT01407237.
- Subjects
RENIN-angiotensin system; LIPOCALIN-2; HIV; CLINICAL trial registries; TUMOR necrosis factors
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 9, p1420
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz346