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- Title
Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal-Human Interface in Vietnam, 2003-2010.
- Authors
Creanga, Adrian; Nguyen Le Khanh Hang; Vuong Duc Cuong; Nguyen, Ha T.; Hoang Vu Mai Phuong; Le Thi Thanh; Nguyen Co Thach; Pham Thi Hien; Nguyen Tung; Yunho Jang; Balish, Amanda; Nguyen Hoang Dang; Mai Thuy Duong; Ngo Thu Huong; Do Ngoc Hoa; Nguyen Dang Tho; Klimov, Alexander; Kapella, Bryan K.; Gubareva, Larisa; Kile, James C.
- Abstract
Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the animal-human interface remain a major concern for emergence of viruses with pandemic potential. To understand the relationship of H5N1 viruses circulating in poultry and those isolated from humans, comprehensive phylogenetic and molecular analyses of viruses collected from both hosts in Vietnam between 2003 and 2010 were performed. We examined the temporal and spatial distribution of human cases relative to H5N1 poultry outbreaks and characterized the genetic lineages and amino acid substitutions in each gene segment identified in humans relative to closely related viruses from avian hosts. Six hemagglutinin clades and 8 genotypes were identified in humans, all of which were initially identified in poultry. Several amino acid mutations throughout the genomes of viruses isolated from humans were identified, indicating the potential for poultry viruses infecting humans to rapidly acquire molecular markers associated with mammalian adaptation and antiviral resistance.
- Subjects
VIETNAM; H5N1 Influenza; MICROBIAL virulence; POULTRY viruses; PHYLOGENY; HEMAGGLUTININ; EPIDEMIOLOGY
- Publication
Journal of Infectious Diseases, 2017, Vol 216, pS529
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix003