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- Title
The mammalian Nek1 kinase is involved in primary cilium formation
- Authors
Shalom, Ohad; Shalva, Nechama; Altschuler, Yoram; Motro, Benny
- Abstract
Abstract: Recent studies implicate primary cilium (PC) proteins in the etiologies of various polycystic kidney diseases (PKD). NIMA-related kinases (NRKs) are conserved serine/threonine kinases, which are usually defined as ‘mitotic kinases’. Murine mutants for the NRKs, nek1 (kat mice) suffer from PKD, suggesting that it may be involved in cilium control. We demonstrated herein that Nek1 is localized to basal body region and that Nek1 overexpression inhibits ciliogenesis in Madin–Darby canine kidney epithelial cells. The number of primary cilia is dramatically reduced in kat2J mouse embryonic fibroblasts culture. It is thus hypothesized that Nek1 links cell cycle progression and the PC cycle.
- Subjects
POLYCYSTIC kidney disease; EPITHELIAL cells; CELL cycle; PROTEIN kinases
- Publication
FEBS Letters, 2008, Vol 582, Issue 10, p1465
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.03.036