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Title
Asymmetric Synthesis of Highly Substituted β-Lactones by Nucleophile-Catalyzed [2+2] Cycloadditions of Disubstituted Ketenes with AldehydesWe thank Ivory D. Hills for X-ray crystallographic studies. Support has been provided by the National Institutes of Health (National Institute of General Medical Sciences: R01-GM57034; National Cancer Institute: training grant CA009112), Merck, and Novartis. Funding for the MIT Department of Chemistry Instrumentation Facility has been furnished in part by NSF CHE-9808061 and NSF DBI-9729592.