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- Title
Taurine increases cell proliferation and generates an increase in [Mg<sup>2+</sup>]i accompanied by ERK 1/2 activation in human osteoblast cells
- Authors
Jeon, Seol-Hee; Lee, Mun-Young; Kim, Shang-Jin; Joe, Sung-Gun; Kim, Gi-Beum; Kim, In-Shik; Kim, Nam-Soo; Hong, Chul-Un; Kim, Sung-Zoo; Kim, Jin-Shang; Kang, Hyung-Sub
- Abstract
Abstract: Taurine has been reported to influence bone metabolism, and its specific transport system, the taurine transporter, is expressed in osteoblasts. The mean [Mg2+]i was 0.51±0.01mM in normal culture media. Taurine caused an increase in [Mg2+]i by 0.72±0.04mM in human osteoblast (HOB) cells. This increment in [Mg2+]i was inhibited significantly by PD98059, nifedipine, lidocaine, and imipramine. Taurine was also shown to stimulate the activation of ERK 1/2. This taurine-stimulated ERK 1/2 activation was inhibited by PD98059. In the present study, taurine was shown to increase cell proliferation and generate an increase in [Mg2+]i accompanied by ERK 1/2 activation in HOB cells.
- Subjects
TAURINE; CELL proliferation; SULFONIC acids; CALCIUM antagonists
- Publication
FEBS Letters, 2007, Vol 581, Issue 30, p5929
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.035