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- Title
A possible flip-flop genetic mechanism for reciprocal gene expression
- Authors
Chiusano, Maria Luisa; Di Giaimo, Rossella; Potenza, Nicoletta; Russo, Giuseppina M.R.; Geraci, Giuseppe; del Gaudio, Rosanna
- Abstract
Abstract: Innexins are a family of transmembrane proteins involved in the formation of gap junctions, specific intercellular channels, in invertebrates. Analyses of the entire innexin family during Drosophila melanogaster embryonic development shows the occurrence of complex and specific patterns of expression of the different genes. Innexins inx-2 and inx-7, in general, do not appear to exhibit extensive co-expression in different D. melanogaster cellular compartments. We propose here a new and robust mechanism, based on our analysis of the genomic organization of inx-2 and inx-7, that structurally justifies the reciprocal expression of genes.
- Subjects
GENE expression; GENETIC regulation; NUCLEIC acids; DROSOPHILA
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p4919
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.07.094