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- Title
The impact of ETOH intoxication on the development of admission coagulopathy after traumatic brain injury: a prospective evaluation.
- Authors
Karamanos, E.; Sivrikoz, E.; Talving, P.; Inaba, K.; Resnick, S.; Demetriades, D.
- Abstract
Introduction: Coagulopathy after severe traumatic brain injury (sTBI) results in a ten-fold increased risk of death. Our aim was to investigate the effect of ETOH intoxication on admission coagulopathy after sTBI. Methods: Patients with sTBI [Glasgow Coma Scale <9 or evidence of intracranial pathology on computed tomography (CT)] from 1/2010 to 12/2011 were prospectively enrolled. Demographics, clinical characteristics, laboratory values, head CT scan findings, physical examination, injury severity indices, and interventions were recorded. ETOH blood levels were obtained. The incidence of admission coagulopathy was compared between patients who were ETOH-positive (ETOH+) and those who were ETOH-negative (ETOH−). Logistic regression was performed to identify independent risk factors. Results: A total of 216 patients were enrolled. 20.4 % were ETOH+. Admission coagulopathy was significantly lower for ETOH+ patients (15.9 vs. 39.0 %, adjusted p = 0.020). Prothrombin time (PT) and International Normalized Ratio (INR) on admission were significantly lower for ETOH+ patients (16.7 vs. 14.3, adjusted p = 0.016 and 1.35 vs. 1.13, adjusted p = 0.040, respectively). Injury Severity Score ≥25, hypotension, and loss of gray/white differential were identified as independent risk factors for the development of admission coagulopathy. ETOH intoxication was the only protective predictor [AOR (95 % CI): 0.32 (0.12, 0.84), adjusted p = 0.021]. Conclusions: ETOH intoxication is associated with a lower incidence of admission coagulopathy in patients with sTBI. Further research is warranted.
- Subjects
CALIFORNIA; COMPLICATIONS of brain injuries; BLOOD coagulation disorders; BRAIN injuries; CONFIDENCE intervals; STATISTICAL correlation; EPIDEMIOLOGY; FISHER exact test; HOSPITAL admission &; discharge; LONGITUDINAL method; PATIENTS; STATISTICS; T-test (Statistics); U-statistics; LOGISTIC regression analysis; DATA analysis; SEVERITY of illness index; DATA analysis software; DESCRIPTIVE statistics; GLASGOW Coma Scale; ALCOHOLIC intoxication
- Publication
European Journal of Trauma & Emergency Surgery, 2014, Vol 40, Issue 1, p45
- ISSN
1863-9933
- Publication type
Article
- DOI
10.1007/s00068-013-0308-0