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- Title
Pyrogallol impairs staphylococcal biofilm formation via induction of bacterial oxidative stress.
- Authors
Roese, Katharina H C; Torlone, Christina; Cooper, Lauren A; Esposito, Lee; Deveau, Amy M; Röse, Ursula S R; Burkholder, Kristin M
- Abstract
Aims To examine the effect of the phenolic compound pyrogallol on staphylococcal biofilm formation. Methods and results In crystal violet biofilm assays, pyrogallol-reduced biofilm formation in Staphylococcus epidermidis ATCC 35984, Staph. epidermidis NRRL-B41021, Staphylococcus aureus USA300, and Staph. aureus Newman, without significantly impairing bacterial viability. Pyrogallol-mediated impairment of biofilm formation was likely due to induction of bacterial oxidative stress, as its effect was greater in catalase-deficient versus WT Staph. aureus , and biofilm production was rescued by exogenous catalase. The effect of pyrogallol on staphylococcal biofilm formation mirrored that of the known oxidant hydrogen peroxide, which also reduced biofilm formation in a dose-dependent manner. Conclusions Pyrogallol reduces biofilm formation in S. aureus and Staph. epidermidis in a mechanism involving induction of bacterial oxidative stress.
- Subjects
OXIDATIVE stress; BIOFILMS; GENTIAN violet; STAPHYLOCOCCUS epidermidis; HYDROGEN peroxide; EXOTOXIN
- Publication
Journal of Applied Microbiology, 2023, Vol 134, Issue 12, p1
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1093/jambio/lxad270