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- Title
Adult myeloid leukaemia and radon exposure: a Bayesian model for a case-control study with error in covariates.
- Authors
Toti, Simona; Biggeri, Annibale; Forastiere, Francesco
- Abstract
The possible association between radon exposure in dwellings and adult myeloid leukaemia had been explored in an Italian province by a case-control study. A total of 44 cases and 211 controls were selected from death certificates file. No association had been found in the original study (OR = 0.58 for > 185 vs 80 ⩽Bq/cm). Here we reanalyse the data taking into account the measurement error of radon concentration and the presence of missing data. A Bayesian hierarchical model with error in covariates is proposed which allows appropriate imputation of missing values. The general conclusion of no evidence of association with radon does not change, but a negative association is not observed anymore (OR = 0.99 for > 185 vs 80 ⩽Bq/cm). After adjusting for residential house radon and gamma radiation, and for the multilevel data structure, geological features of the soil is associated with adult myeloid leukaemia risk (OR = 2.14, 95 per cent Cr.I. 1.0-5.5). Copyright © 2005 John Wiley & Sons, Ltd.
- Publication
Statistics in Medicine, 2005, Vol 24, Issue 12, p1849
- ISSN
0277-6715
- Publication type
Article
- DOI
10.1002/sim.2064