We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Infection with Mycobacterium tuberculosis Beijing Genotype Strains Is Associated with Polymorphisms in SLC11A1/NRAMP1 in Indonesian Patients with Tuberculosis.
- Authors
van Crevel, Reinout; Parwati, Ida; Sahiratmadja, Edhyana; Marzuki, Sangkot; Ottenhoff, Tom H. M.; Netea, Mihai G.; van der Ven, Andre; Nelwan, Ronald H.; van der Meer, Jos W.; Alisjahbana, Bachti; van de Vosse, Esther
- Abstract
Differences in host immune genes may predispose to tuberculosis caused by particular Mycobacterium tuberculosis genotypes. We examined this hypothesis in Indonesia by spoligotyping M. tuberculosis isolates recovered from 336 patients with pulmonary tuberculosis and typing the patients' SLC11A1 gene (formerly known as "NRAMP1"), which is involved in susceptibility to tuberculosis. The M. tuberculosis Beijing genotype, which comprised 29.8% of all isolates, was strongly associated with 2 polymorphisms in SLC11A1: the D543N G allele (odds ratio [OR], 2.15; P=.005 and the 3′ untranslated region (3′UTR) insertion/insertion genotype (OR, 2.5; P<! .001). This finding supports the hypothesis of coevolution of M. tuberculosis and the human immune system.
- Subjects
INDONESIA; MYCOBACTERIUM tuberculosis; GENETIC polymorphisms; HYPOTHESIS; BACTERIOPHAGE typing; TUBERCULOSIS; COEVOLUTION; HUMAN immunogenetics; IMMUNE system; CLINICAL trials
- Publication
Journal of Infectious Diseases, 2009, Vol 200, Issue 11, p1671
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/648477