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- Title
Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma.
- Authors
Burbelo PD; Issa AT; Ching KH; Wyvill KM; Little RF; Iadarola MJ; Kovacs JA; Yarchoan R; Burbelo, Peter D; Issa, Alexandra T; Ching, Kathryn H; Wyvill, Kathleen M; Little, Richard F; Iadarola, Michael J; Kovacs, Joseph A; Yarchoan, Robert
- Abstract
Antibody responses against lytic and latent Kaposi sarcoma (KS)-associated herpesvirus antigens were investigated in patients with KS, multicentric Castleman disease (MCD), and primary effusion lymphoma. Antibodies against the lytic antigen K8.1 were 5-fold higher in patients with MCD than those with KS, whereas antibodies to the sum of latent antigens v-cyclin and LANA were 27-fold higher in patients with KS, compared with patients with MCD (P < 001). The sum of anti-v-cyclin and anti-LANA antibody titers discriminated patients with KS from those with MCD and KS with 93% sensitivity and 83% specificity. These results suggest that antibody responses to lytic and latent KS-associated herpesvirus antigens differ in these diseases.
- Publication
Journal of Infectious Diseases, 2010, Vol 201, Issue 12, p1919
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/652869