We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effectiveness of the 23-Valent Polysaccharide Vaccine against Invasive Pneumococcal Disease in Navajo Adults.
- Authors
Benin, Andrea L.; O'Brien, Katherine L.; Watt, James P.; Reid, Raymond; Zell, Elizabeth R.; Katz, Scott; Donaldson, Connie; Parkinson, Alan; Schuchat, Anne; Santosham, Mathuram; Whitney, Cynthia G.
- Abstract
Invasive pneumococcal disease occurs 2-3-fold more often among Navajo adults than among adults in the general United States population. The objective of this observational study was to determine the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) among Navajo adults. Active surveillance identified cases of invasive pneumococcal disease during 1996-1997. Three control patients per case patient were matched according to underlying medical conditions, sex, age, and location of medical care. Effectiveness was calculated by regression analysis of case-control sets and by indirect cohort methodology. Diabetes and alcoholism occurred in 41% and 43% of 108 case patients, respectively; 62% of case patients and 64% of control patients were immunized. Overall vaccine effectiveness was 26% (95% confidence interval [CI], -29% to 58%); 15% (95% CI, -116% to 67%) for patients with diabetes and -5% (95% CI, -141% to 54%) for patients with alcoholism. Overall vaccine effectiveness, as determined by use of the indirect cohort methodology, was 35% (95% CI, -33% to 69%). PPV23 was not significantly effective among Navajo adults and may be inadequate to prevent serious pneumococcal disease in this population.
- Subjects
UNITED States; POLYSACCHARIDES; VACCINATION; NAVAJO (North American people); REGRESSION analysis
- Publication
Journal of Infectious Diseases, 2003, Vol 188, Issue 1, p81
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/375782