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- Title
Tandem high-dose therapy in relapsed and refractory B-cell lymphoma: results of a prospective phase II trial of myeloablative chemotherapy, followed by escalated radioimmunotherapy with I-anti-CD20 antibody and stem cell rescue.
- Authors
Hohloch, Karin; Sahlmann, Carsten; Lakhani, Vijai; Wulf, Gerald; Glaß, Bertram; Hasenkamp, Justin; Meller, Johannes; Riggert, Joachim; Trümper, Lorenz; Griesinger, Frank
- Abstract
A phase II trial evaluated safety, feasibility and efficacy of a sequential tandem approach combining myeloablative BEAM chemotherapy and autologous stem cell transplantation (ASCT) with myeloablative radioimmunotherapy (HD-RIT), with I-anti-CD20 antibody (I-rituximab), followed by a second ASCT in patients with relapsed or refractory CD20+ B-cell lymphoma. According to protocol, 16 patients with relapsed ( n = 14) and refractory ( n = 2) CD20+ B-cell lymphoma received salvage therapy with rituximab and Dexa-BEAM, followed by BEAM (HD chemotherapy) and high-dose myeloablative radioimmunotherapy 2-6 months after BEAM. Nine of 16 patients received HD-RIT; seven patients were excluded before HD-RIT because of toxicity or progressive disease. Disease histologies were follicular lymphoma (FL) grades 1 and 2 ( n = 4), transformed follicular (FL 3b; n = 6), diffuse large B-cell (DLBCL; n = 4), mantle cell ( n = 1) and marginal zone lymphoma ( n = 1). After a median follow-up of 50.4 months for OS and 39.7 months for progression-free survival (PFS), estimated 4-year OS and PFS were 67% and 64%, respectively. The estimated 4-year OS and PFS for patients with FL were 80% and 78%, respectively. Toxicity was significant, including one fatal outcome due to pneumonitis. Tandem transplants consisting of HD chemotherapy followed by HD-RIT with I-coupled anti-CD20 are manageable and effective but toxic treatment modalities for relapsed poor prognosis CD20+ B-NHL.
- Subjects
STEM cell transplantation research; RADIOIMMUNOTHERAPY; RITUXIMAB; B cells; DISEASE progression; LYMPHOMAS; SALVAGE therapy; PNEUMONIA
- Publication
Annals of Hematology, 2011, Vol 90, Issue 11, p1307
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-011-1199-y