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- Title
CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid.
- Authors
Bornhauser, Martin; Jenke, Andreas; Freiberg-Richter, Jens; Radke, Jörgen; Schuler, Ulrich S.; Mohr, Brigitte; Ehninger, Gerhard; Schleyer, Eberhard
- Abstract
Imatinib mesylate (STI571) is a very effective treatment option for Ph+ chronic myeloid leukemia (CML) in chronic phase. Secondary treatment failures have mostly been observed in patients with advanced stages of disease. We report the case of a patient who unexpectedly experienced blast crisis of the central nervous system although having achieved complete cytogenetic remission in the bone marrow. The levels of STI571 and its metabolite N-desmethyl STI were 40-fold lower in the cerebral spine fluid than in plasma. The risk of CNS disease has to be kept in mind when patients with CML in chronic phase who are at an increased risk for blastic transformation are treated with imatinib mesylate.
- Subjects
MYELOID leukemia; BONE marrow diseases; BONE marrow; THERAPEUTICS
- Publication
Annals of Hematology, 2004, Vol 83, Issue 6, p401
- ISSN
0939-5555
- Publication type
Article
- DOI
10.1007/s00277-003-0829-4