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- Title
Esophageal Manometry, pH Testing, Endoscopy, and Videofluoroscopy in Patients With Globus Sensation.
- Authors
Van Daele, Douglas J.
- Abstract
<bold>Objectives/hypothesis: </bold>Combine techniques commonly employed in the clinical workup of patients with isolated globus sensation to identify the most common pharyngoesophageal abnormality. The primary aim was to retrospectively review high-resolution manometry, pH probe testing, contrast videofluoroscopy, and endoscopy studies in patients with a primary complaint of globus sensation. The specific hypothesis was esophageal high-resolution manometry identifies the most significant proportion of abnormalities compared to all other modalities.<bold>Study Design: </bold>Retrospective cohort study.<bold>Methods: </bold>An inclusive retrospective chart review was performed for patients evaluated between 2009 and 2016 with the primary complaint of globus sensation. Age at testing, self-identified gender, associated diagnoses, and results from each modality were collected. Descriptive statistics and pairwise comparisons were performed as well as sensitivity and specificity calculations.<bold>Results: </bold>One hundred seventy-two patients met inclusion criteria. The cohort had an age range of 22.7 to 88.5 years and was predominantly female. Esophageal manometry identified abnormalities in 62.8% of patients, and pH testing identified abnormal acidification in approximately 20%. The esophagram identified abnormalities in 24% of patients, and esophagogastroduodenoscopy identified abnormalities in 22%. Modified barium swallows were normal in 93% of patients. Measures of sensitivity and specificity of other modalities were poor compared to esophageal manometry and pH testing.<bold>Conclusions: </bold>Patients with isolated globus sensation have evidence of esophageal dysmotility and laryngopharyngeal and gastroesophageal reflux disease in high proportions. Esophageal high-resolution manometry testing identifies the greatest proportion of abnormalities of the investigated modalities.<bold>Level Of Evidence: </bold>4 Laryngoscope, 130:2120-2125, 2020.
- Subjects
VIDEOFLUOROSCOPY; ESOPHAGEAL motility disorders; SENSES; GASTROESOPHAGEAL reflux; ENDOSCOPY; GASTROESOPHAGEAL reflux diagnosis; ESOPHAGOSCOPY; ESOPHAGUS; CINERADIOGRAPHY; MANOMETERS; DIFFERENTIAL diagnosis; RETROSPECTIVE studies; PATIENT monitoring; DISEASE complications
- Publication
Laryngoscope, 2020, Vol 130, Issue 9, p2120
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.28289