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- Title
Isolated Tumor Cells and Circulating CK20 mRNA in pN0 Colorectal Cancer Patients.
- Authors
Sze-Chuen Wong, Cesar; Mong-Tong Cheung; Buig-Yue Ma, Brigette; Pun Hui, Edwin; Chak-Lam Chan, Alex; Chi-Kin Chan; King-Chung Lee; Wah Cheuk; Yan-Yee Lam, Money; Chi-Keung Wong, Manson; Ming-Lok Chan, Charles; Kwok-Cheung Chan, John; Tak-Cheung Chan, Anthony
- Abstract
Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Results showed that 29 out of 56 (52%) lymph node specimens had CK20-positive cells (range: 1-35). Follow-up of the patients for 12 months indicated that 4 patients (7%) had CRC metastases to liver, lung, and bone. In addition, 8 out of 24 (33%) samples had at least 2-fold circulating CK20 mRNA expression higher than the pooled normal sample. This study provides evidence that CK20-positive cells were found in the lymph nodes and differentially expressed circulating CK20 mRNA was also detected in the blood from patients with pN0 CRC. Long-term follow-up is necessary to study their prognostic use in patients with nonmetastatic CRC.
- Subjects
METASTASIS; COLON cancer; LYMPH nodes; PARAFFIN wax; PROGNOSIS
- Publication
International Journal of Surgical Pathology, 2008, Vol 16, Issue 2, p119
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/1066896907311901