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- Title
Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium Enhygromyxa sp.
- Authors
Zhang, Fan; Braun, Doug R.; Rajski, Scott R.; DeMaria, Don; Bugni, Tim S.
- Abstract
To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium Enhygromyxa sp. Their structures were elucidated by HRESIMS and comprehensive NMR data analyses. Compounds 1 and 2, which contain a rare trisubstituted-pyrazinone core, represent a unique class of molecules from Enhygromyxa sp.
- Subjects
MARINE natural products; NATURAL products; METABOLITES; MYXOBACTERALES; GENE clusters; DATA analysis
- Publication
Marine Drugs, 2019, Vol 17, Issue 12, p698
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17120698