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- Title
Thyroid Hormone-Activated Signaling Pathways are Essential for Development of Intestinal Stem Cells.
- Authors
Kenta Fujimoto; Yuki Shibata; Takashi Hasebe
- Abstract
Intestinal homeostasis is maintained by strict regulation of stem cell function. In mammals, several signaling pathways, including the formation of stem cell niches, are involved in stem cell regulation. However, little is known of the molecular mechanisms involved in postembryonic maturation of the vertebrate intestine, that is, the acquisition of cell renewal systems, including stem cell development and niche formation. Using thyroid hormone (TH)-dependent intestinal remodeling during amphibian metamorphosis as a model to study these mechanisms, we found that several signaling pathways, including the SHH/BMP4, WNT, Notch, and Hippo pathways, are regulated by TH and involved in stem cell regulation. In this review, we highlight findings regarding the role of these signaling pathways and discuss potential future avenues of study.
- Subjects
STEM cell niches; CELLULAR signal transduction; STEM cells; CELLULAR control mechanisms; CELL physiology
- Publication
Journal of Nippon Medical School, 2023, Vol 90, Issue 3, p246
- ISSN
1345-4676
- Publication type
Article
- DOI
10.1272/jnms.JNMS.2023_90-308