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- Title
Potential of microbial-derived biosurfactants for oral applications–a systematic review.
- Authors
Khairunnisa, Z.; Tuygunov, N.; Cahyanto, A.; Aznita, W. H.; Purwasena, I. A.; Noor, N. S.M.; Azami, N. H.; Zakaria, M. N.
- Abstract
Background: Biosurfactants are amphiphilic compounds produced by various microorganisms. Current research evaluates diverse types of biosurfactants against a range of oral pathogens. Objectives: This systematic review aims to explore the potential of microbial-derived biosurfactants for oral applications. Methodology: A systematic literature search was performed utilizing PubMed-MEDLINE, Scopus, and Web of Science databases with designated keywords. The results were registered in the PROSPERO database and conducted following the PRISMA checklist. Criteria for eligibility, guided by the PICOS framework, were established for both inclusion and exclusion criteria. The QUIN tool was used to assess the bias risk for in vitro dentistry studies. Results: Among the initial 357 findings, ten studies were selected for further analysis. The outcomes of this systematic review reveal that both crude and purified forms of biosurfactants exhibit antimicrobial and antibiofilm properties against various oral pathogens. Noteworthy applications of biosurfactants in oral products include mouthwash, toothpaste, and implant coating. Conclusion: Biosurfactants have garnered considerable interest and demonstrated their potential for application in oral health. This is attributed to their surface-active properties, antiadhesive activity, biodegradability, and antimicrobial effectiveness against a variety of oral microorganisms, including bacteria and fungi.
- Subjects
BIOFILMS; RESEARCH funding; ANTI-infective agents; ORAL diseases; SYSTEMATIC reviews; MEDLINE; SURFACE active agents; DENTIFRICES; ONLINE information services; MOUTHWASHES; ORAL health; PHARMACODYNAMICS
- Publication
BMC Oral Health, 2024, Vol 24, Issue 1, p1
- ISSN
1472-6831
- Publication type
Article
- DOI
10.1186/s12903-024-04479-0