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- Title
Synergistic Strategies for Castration-Resistant Prostate Cancer: Targeting AR-V7, Exploring Natural Compounds, and Optimizing FDA-Approved Therapies.
- Authors
Rahman, Muntajin; Akter, Khadija; Ahmed, Kazi Rejvee; Fahim, Md. Maharub Hossain; Aktary, Nahida; Park, Moon Nyeo; Shin, Sang-Won; Kim, Bonglee
- Abstract
Simple Summary: Castration-resistant prostate cancer (CRPC) resists standard therapies, partly due to the androgen receptor variant AR-V7. Conventional treatments like chemotherapy and radiation have limited success and significant side effects. Natural compounds from herbal medicine offer promise as complementary therapies. This review examines how these natural compounds can improve treatment outcomes and reduce side effects, presenting a safer and more effective approach to managing CRPC and overcoming resistance to conventional therapies. Castration-resistant prostate cancer (CRPC) remains a significant therapeutic challenge due to its resistance to standard androgen deprivation therapy (ADT). The emergence of androgen receptor splice variant 7 (AR-V7) has been implicated in CRPC progression, contributing to treatment resistance. Current treatments, including first-generation chemotherapy, androgen receptor blockers, radiation therapy, immune therapy, and PARP inhibitors, often come with substantial side effects and limited efficacy. Natural compounds, particularly those derived from herbal medicine, have garnered increasing interest as adjunctive therapeutic agents against CRPC. This review explores the role of AR-V7 in CRPC and highlights the promising benefits of natural compounds as complementary treatments to conventional drugs in reducing CRPC and overcoming therapeutic resistance. We delve into the mechanisms of action underlying the anti-CRPC effects of natural compounds, showcasing their potential to enhance therapeutic outcomes while mitigating the side effects associated with conventional therapies. The exploration of natural compounds offers promising avenues for developing novel treatment strategies that enhance therapeutic outcomes and reduce the adverse effects of conventional CRPC therapies. These compounds provide a safer, more effective approach to managing CRPC, representing a significant advancement in improving patient care.
- Subjects
CASTRATION-resistant prostate cancer; ANTIANDROGENS; DRUG resistance in cancer cells; PATIENT safety; HERBAL medicine; UNITED States. Food &; Drug Administration; TREATMENT effectiveness; DRUG approval; ALTERNATIVE medicine; ANDROGEN receptors
- Publication
Cancers, 2024, Vol 16, Issue 16, p2777
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16162777