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- Title
Noninvasive Ventilation in Critically Ill Patients With Severe Acute Respiratory Infections.
- Authors
Jabri, Ghaida; Alotaibi, Farah; Ahmed, Amjad M.; Jose, Jesna; Alenezi, Farhan Z.; Sadat, Musharaf; Bin Humaid, Felwa; Al-Hameed, Fahad; Memon, Javed; Al Khatib, Kasim; Alsuayb, Abdullah M.; AlObaidi, Mohammed; Al Mutairi, Mohammed; Alanaizi, Ahmad A.; Alghamdi, Fuad; Arabi, Yaseen M.
- Abstract
BACKGROUND: The objective of this study was to evaluate the association between noninvasive ventilation (NIV) compared with invasive ventilation and mortality in subjects with severe acute respiratory infection. METHODS: This was a retrospective multi-center study of subjects with severe acute respiratory infection treated with ventilatory support between September 2012 and June 2018. We compared the 90-d mortality of subjects managed initially with NIV (NIV group) with those managed with invasive ventilation only (invasive ventilation group), adjusting by propensity score. RESULTS: Of 383 subjects, 189 (49%) were in the NIV group and 194 (51%) were in the invasive ventilation group. Of the subjects initially treated with NIV, 117 (62%) were eventually intubated. Crude 90-d mortality was lower in the NIV group versus the invasive ventilation group (42 [22.2%] vs 77 [39.7%]; P < .001). After propensity score adjustment, NIV was associated with lower 90-d mortality than invasive ventilation (odds ratio 0.54, 95% CI 0.38-0.76; P < .001). The association of NIV with mortality compared with invasive ventilation was not different across the studied subgroups. CONCLUSIONS: In subjects with severe acute respiratory infection and acute respiratory failure, NIV was commonly used. NIV was associated with a lower 90-d mortality. The observed high failure rate suggests the need for further research to optimize patient selection and facilitate early recognition of NIV failure.
- Subjects
SAUDI Arabia; SARS disease; CRITICALLY ill; PATIENTS; RETROSPECTIVE studies; DESCRIPTIVE statistics; MANN Whitney U Test; GLASGOW Coma Scale; OPERATIVE surgery; LONGITUDINAL method; ODDS ratio; KAPLAN-Meier estimator; LOG-rank test; ARTIFICIAL respiration; RESEARCH; CONFIDENCE intervals; DATA analysis software; REGRESSION analysis
- Publication
Respiratory Care, 2024, Vol 69, Issue 9, p1138
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.11286