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- Title
Acrokeratosis paraneoplastica Bazex syndrome associated with esophageal squamocellular carcinoma.
- Authors
Medenica, Ljiljana; Gajić-Veljić, Mirjana; Škiljević, Dušan; Peško, Predrag
- Abstract
Background. Acrokeratosis paraneoplastica Bazex (APB) is a very rare disease in the group of obligate paraneoplastic dermatoses, associated mostly with squamous cell carcinoma of the upper aerodigestive tract and metastatic cervical lymphadenopathy. The disease is characterized by violaceous erythemosquamous changes on the acral regions. This entity was first reported by Bazex in 1965. About 160 cases have been presented so far. Case report. We presented a patient with a three-month history of violaceous erythema, edema, erosions and scaling on the acral regions, elbows and knees and severe nail dystrophy. When the diagnosis was established, he did not have any symptom of internal malignancy. Esophagogastroscopy revealed ulcerovegetant lesion of the esophagus, while histology showed squamocellular invasive carcinoma. Surgical tumor removal resulted in significant improvement of skin changes in 15 days. Unfortunately, four months later, extensive skin lesions pointed to metastasis of squamous cell carcinoma. Conclusion. Skin changes can precede a few years the first manifestations of neoplasia. The course of the disease in our patient proved that APB is a specific marker of underlying malignancy.
- Subjects
PARANEOPLASTIC syndromes; ESOPHAGEAL cancer; SQUAMOUS cell carcinoma; SKIN diseases; DIAGNOSIS
- Publication
Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 2008, Vol 65, Issue 6, p485
- ISSN
0042-8450
- Publication type
Article
- DOI
10.2298/VSP0806485M