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- Title
Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report.
- Authors
Aldegheri, Luana; Kharrat, Feras; Conti, Andrea; Monica, Fabio; Busa, Francesca; Campisciano, Giuseppina; Zanotta, Nunzia; Cason, Carolina; Comar, Manola
- Abstract
Recent evidence has highlighted the role of the gut–brain axis in the progression of autism spectrum disorder (ASD), with significant changes in the gut microbiome of individuals with this condition. This report investigates the effects of probiotics and human milk oligosaccharide (HMO) supplements on the gut microbiome, inflammatory cytokine profile, and clinical outcomes in an ASD adolescent with chronic gastrointestinal dysfunction and cognitive impairment. Following treatment, we observed a decrease in proinflammatory cytokines' concentration alongside Sutterella relative abundance, a bacterium reported to be linked with gastrointestinal diseases. Also, we reported a notable increase in mood stability. The study aims to evaluate the use of gut microbiome-based therapy in selected ASD patients, highlighting its potential to improve related clinical symptoms.
- Subjects
AUTISM spectrum disorders; BREAST milk; NUCLEOTIDE sequencing; GASTROINTESTINAL diseases; HEALTH maintenance organizations; PROBIOTICS; GUT microbiome
- Publication
Microorganisms, 2024, Vol 12, Issue 8, p1625
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms12081625