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- Title
Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome.
- Authors
Pańczyszyn, Anna; Boniewska-Bernacka, Ewa; Wertel, Iwona; Sadakierska-Chudy, Anna; Goc, Anna
- Abstract
The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes.
- Subjects
REPRODUCTIVE technology; CELLULAR aging; GAMETES; FERTILIZATION in vitro; SIRTUINS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8652
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168652