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- Title
Genetic and Immunological Characterization of Fibrinogen Inclusion Bodies in Patients with Hepatic Fibrinogen Storage and Liver Disease.
- Authors
MEDICINA, DANIELA; FABBRETTI, GIOVANNA; BRENNAN, STEPHEN O.; GEORGE, PETER M.; KUDRYK, BO; CALLEA, FRANCESCO
- Abstract
A bstract: Fibrinogen storage in liver cells can occur under three different morphological inclusions. Type I contain all three fibrinogen chains (Aα, Bβ, and γ) as well as D and E fragments, whereas type II and III lack Bβ as well as D and E fragments. Patients with type I inclusions carry a point mutation (γ284 Gly-Arg). The mutation is not present in patients with type II and III inclusions. These results appear to suggest that the three various phenotypic expressions (i.e., morphological variants) reflect different genetical abnormalities of fibrinogen.
- Publication
Annals of the New York Academy of Sciences, 2001, Vol 936, Issue 1, p522
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2001.tb03538.x