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- Title
On the pathophysiology of vitiligo: possible treatment options.
- Authors
Boissy, Raymond E.; Dell'Anna, Maria Lucia; Picardo, Mauro
- Abstract
Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.
- Subjects
VITILIGO; PIGMENTATION disorders; IMMUNE system; MELANOCYTES; SKIN diseases; THERAPEUTICS; EPITHELIAL cells; SKIN
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2012, Vol 78, Issue 1, p24
- ISSN
0378-6323
- Publication type
journal article
- DOI
10.4103/0378-6323.90943