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- Title
Citrobacter rodentium: infection, inflammation and the microbiota.
- Authors
Collins, James W.; Keeney, Kristie M.; Crepin, Valerie F.; Rathinam, Vijay A. K.; Fitzgerald, Katherine A.; Finlay, B. Brett; Frankel, Gad
- Abstract
Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.
- Subjects
CITROBACTER; INFECTION; ESCHERICHIA coli; INFLAMMATION; MEDICAL microbiology; PATHOGENIC microorganisms
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 9, p612
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3315