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- Title
Functional Diversity of SIRT7 Across Cellular Compartments: Insights and Perspectives.
- Authors
Wu, Songtao; Jia, Shengnan
- Abstract
Posttranslational modifications (PTMs) play important roles in the regulation of protein function. Acetylation and deacetylation are among the most important PTMs. SIRT7 is a relatively understudied member of the sirtuin family, but recent studies have revealed that it plays a regulatory role in a variety of cellular activities, such as genome stabilization and repair, gene translation, ribosome production and other important processes. Here, we provide a list of the functions and mechanisms of SIRT7 in various organelles and show the important role of SIRT7 in maintaining normal cell function.
- Subjects
POST-translational modification; CELL physiology; DEACETYLATION; ACETYLATION; GENETIC translation; CELL metabolism
- Publication
Cell Biochemistry & Biophysics, 2023, Vol 81, Issue 3, p409
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-023-01162-z