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- Title
Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib.
- Authors
de Vos, J.; Ramos Vega, S.; Noorman, E.; de Vos, P.
- Abstract
In human medicine, primary frontal sinus squamous cell carcinoma (pFS-SCC) is not frequently reported. In veterinary medicine, frontal sinus SCC is exclusively described as an extension of nasal cavity SCC. To our knowledge, this is the first publication concerning canine pFS-SCC, diagnosed using histology or cytology and medical imaging, in three dogs. The tumours extended into the orbit or brain cavity, without nasal involvement. Treatment was initiated with piroxicam-carboplatin. Prolongation of carboplatin delivery with a low dose intensity was performed on dogs with a favourable initial response. Dog 1 achieved a complete remission (CR), but was euthanized 344 days after start of therapy. Dog 2, still alive 3 years after start of therapy and in CR, received 14 carboplatin deliveries. In dog 3, after changing the treatment protocol into piroxicam-toceranib, a significant tumour reduction occurred, but the dog was euthanized after 195 days because of a relapse.
- Subjects
FRONTAL sinus; SQUAMOUS cell carcinoma; CANCER treatment; PIROXICAM; CARBOPLATIN; VETERINARY therapeutics; DOG diseases; DISEASES
- Publication
Veterinary & Comparative Oncology, 2012, Vol 10, Issue 3, p206
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2011.00292.x