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- Title
Antibiotic drug release behavior of poly (vinyl alcohol)/sodium alginate hydrogels.
- Authors
Xie, L.; Wei, H.; Kou, L.; Ren, L.; Zhou, J.
- Abstract
Poly (vinyl alcohol)/sodium alginate hydrogels were prepared by freeze‐thaw followed by calcium ion crosslinking. Chloramphenicol release behavior from the poly (vinyl alcohol)/sodium alginate hydrogels in mimic conditions of gastrointestinal tract was examined. The effects of composition, number of freeze‐thaw cycles and calcium ion concentration on drug release process were investigated. The results showed that the cumulative release amount of chloramphenicol from the hydrogels (crosslinked through 4 freeze‐thaw cycles and immersed in 2 % calcium chloride solution) decreased from 84.3 % to 72.3 % as sodium alginate content increased from 0 % to 75 %. For the hydrogels containing 50 % sodium alginate and immersed in 2 % calcium chloride solution after the freeze‐thaw cycles, cumulative release amount of chloramphenicol decreased from 83.5 % to 76.6 % as the freeze‐thaw cycles increased from 2 to 6. Cumulative release amount of chloramphenicol from the hydrogels containing 50 % sodium alginate and with 4 freeze‐thaw cycles decreased from 79.8 % to 75.6 % when concentration of calcium chloride solution increased from 1 % to 4 %.
- Subjects
SODIUM alginate; FREEZE-thaw cycles; CALCIUM chloride; CALCIUM ions; ALCOHOL; HYDROGELS; CHLORAMPHENICOL; POLYVINYL alcohol
- Publication
Materialwissenschaft und Werkstoffechnik, 2020, Vol 51, Issue 7, p850
- ISSN
0933-5137
- Publication type
Article
- DOI
10.1002/mawe.201900163