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- Title
Solution or Gas Phase ? Oxidation and Radical Formation in Electrospray Ionization Mass Spectrometry (ESI MS).
- Authors
Iftikhar, Imran; Brajter‐Toth, Anna
- Abstract
The relationship between one-electron (e-) oxidation processes and the formation of radical cations of endogenous and exogenous compounds in vivo is of considerable interest. This paper reports on the experiments that allow FTICR mass spectrometric (MS) detection of ion signals that are consistent with the formation of radical cations of caffeine (CA) and theophylline (TP) during electrospray ionization (ESI) in ESI FTICR MS and in on-line electrochemistry (EC)/ESI FTICR MS in positive mode. Significantly, the signals of the radicals of CA•+ and TP•+ can be enhanced by simple modifications of the operating conditions in ESI MS, facilitating investigations of radical formation and related reactions.
- Subjects
ELECTROSPRAY ionization mass spectrometry; RADICAL cations; GAS phase reactions; OXIDATION; ELECTROCHEMISTRY; THEOPHYLLINE
- Publication
Electroanalysis, 2015, Vol 27, Issue 12, p2872
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201500297