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- Title
From C<sub>1</sub> to C<sub>2</sub>: TMSCF<sub>3</sub> as a Precursor for Pentafluoroethylation.
- Authors
Xie, Qiqiang; Li, Lingchun; Zhu, Ziyue; Zhang, Rongyi; Ni, Chuanfa; Hu, Jinbo
- Abstract
Abstract: A highly efficient copper‐mediated aromatic pentafluoroethylation method using TMSCF3 as the sole fluoroalkyl source is described. The reaction proceeds by a key C1 to C2 process, that is, the generation of CuCF3 from TMSCF3, followed by a subsequent spontaneous transformation into CuC2F5. Various aryl iodides were pentafluoroethylated with the TMSCF3‐derived CuC2F5. This method represents the first practical and efficient method for pentafluoroethylation of aryl iodides using commercially available TMSCF3 as a pentafluoroethyl precursor.
- Subjects
CHEMICAL precursors; ETHYLATION; FLUOROALKYL compounds; ARYL iodides; COPPER compounds
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 40, p13395
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201807873