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- Title
Photoinduced Remote Functionalisations by Iminyl Radical Promoted C−C and C−H Bond Cleavage Cascades.
- Authors
Dauncey, Elizabeth M.; Morcillo, Sara P.; Douglas, James J.; Sheikh, Nadeem S.; Leonori, Daniele
- Abstract
Abstract: A photoinduced cascade strategy leading to a variety of differentially functionalised nitriles and ketones has been developed. These reactions rely on the oxidative generation of iminyl radicals from simple oximes. Radical transposition by C(sp3)−(sp3) and C(sp3)−H bond cleavage gives access to distal carbon radicals that undergo SH2 functionalisations. These mild, visible‐light‐mediated procedures can be used for remote fluorination, chlorination, and azidation, and were applied to the modification of bioactive and structurally complex molecules.
- Subjects
IMINYL radicals; PHOTOINDUCED electron transfer; NITRILES; KETONES; RADICALS (Chemistry); FLUORINATION
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 3, p752
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201710790