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- Title
Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation.
- Authors
Li, Junjie; Dirisala, Anjaneyulu; Ge, Zhishen; Wang, Yuheng; Yin, Wei; Ke, Wendong; Toh, Kazuko; Xie, Jinbing; Matsumoto, Yu; Anraku, Yasutaka; Osada, Kensuke; Kataoka, Kazunori
- Abstract
Polymeric nanoreactors (NRs) have distinct advantages to improve chemical reaction efficiency, but the in vivo applications are limited by lack of tissue-specificity. Herein, novel glucose oxidase (GOD)-loaded therapeutic vesicular NRs ( theraNR) are constructed based on a diblock copolymer containing poly(ethylene glycol) (PEG) and copolymerized phenylboronic ester or piperidine-functionalized methacrylate (P(PBEM- co-PEM)). Upon systemic injection, theraNR are inactive in normal tissues. At a tumor site, theraNR are specifically activated by the tumor acidity via improved permeability of the membranes. Hydrogen peroxide (H2O2) production by the catalysis of GOD in theraNR increases tumor oxidative stress significantly. Meanwhile, high levels of H2O2 induce self-destruction of theraNR releasing quinone methide (QM) to deplete glutathione and suppress the antioxidant ability of cancer cells. Finally, theraNR efficiently kill cancer cells and ablate tumors via the synergistic effect.
- Subjects
CHEMICAL reactors; COPOLYMERIZATION; GLUCOSE oxidase; METHACRYLATES; CHEMICAL reactions; POLYMERS; CANCER cells
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 45, p14213
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201706964