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- Title
Lanthanide Luminescence Modulation by Cation-π Interaction in a Bioinspired Scaffold: Selective Detection of Copper(I).
- Authors
Isaac, Manon; Denisov, Sergey A.; Roux, Amandine; Imbert, Daniel; Jonusauskas, Gediminas; McClenaghan, Nathan D.; Sénèque, Olivier
- Abstract
A prototype luminescent turn-on probe for Cu+ (and Ag+) is described, harnessing a selective binding site (log Kass=9.4 and 7.3 for Cu+ and Ag+, respectively) based on the coordinating environment of the bacterial metallo-chaperone CusF, integrated with a terbium-ion-signaling moiety. Cation-π interactions were shown to enhance tryptophan triplet population, which subsequently sensitized, on the microsecond timescale, the long-lived terbium emission, offering a novel approach in bioinspired chemosensor design.
- Subjects
LUMINESCENCE; RARE earth metals; CATIONS; TISSUE scaffolds; COPPER
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 39, p11615
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201505733